Animal Toxicology And/or Pharmacology
A wide range of in vivo studies in mice, rats, dogs, and monkeys, and in vitro studies using rat, monkey, and human hepatocytes suggest that peroxisome proliferation in the liver is a rat-specific finding. However, other effects, including increased liver weights and APTT, occurred in dogs and monkeys at doses giving Css trough levels of the parent terbinafine 23x those seen in humans at the MRHD. Higher doses were not tested.
How And When To Take Terbinafine
The treatment you use will depend on where the infection is on your body and how severe it is.
For large areas of skin, or if the area is hairy, it’s best to use the spray.
Your pharmacist or doctor will tell you how much to use and how long you need to use it for, depending on your infection.
If you buy terbinafine in a pharmacy or supermarket, follow the instructions that come with your medicine.
Interactions With Other Drugs
Any drug, including Lamisil, can have adverse effects with other drugs you may be taking. You may need to temporarily discontinue some of your prescriptions while taking terbinafine. Taking another oral antifungal is also an option, although Lamisil is generally regarded as the most effective.
Lamisil may cause other drugs to work differently or not work at all. Additionally, this medication should not be taken with other drugs which stress the liver or kidneys. Drugs with known negative interactions include but are not limited to the following: blood thinners such as Warfarin or Coumadin, and drugs which affect liver enzymes such as Cimetidine and Rifampin. Tricyclic antidepressants should and SSRI antidepressants should also be avoided while taking terbinafine. Beta blockers should also not be combined with Lamisil.
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How Effective Are Tablets In Treating Nail Fungus
Tablets for the treatment of nail fungus have been tested in several studies. All participants had an infection on their toenails caused by a skin fungus. Overall, the study results showed that tablets are considerably more effective than nail polishes or creams.
One year after a three-month treatment with terbinafine:
- About 17 out of 100 people who didnt have this treatment no longer had a detectable fungal nail infection.
- About 76 out of 100 people who had this treatment no longer had a detectable fungal nail infection.
In other words, the treatment with terbinafine got rid of the fungal infection in about 59 out of 100 people.
Itraconazole also proved to be effective. After one year,
- 7 out of 100 people who didnt have this treatment no longer had a detectable fungal nail infection.
- About 43 out of 100 people who had this treatment no longer had a detectable fungal nail infection.
In other words, the treatment with itraconazole got rid of the fungal infection in about 36 out of 100 people.
Some studies directly compared itraconazole and terbinafine with each other. They confirm that terbinafine is somewhat more effective than itraconazole.
Treatment with breaks is thought to be about as effective as continuous treatment. But that has only been looked into in a few studies.
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Evaluation Of Therapeutic Response
The degrees of improvement were classified as follows: total cure , clinical disease-free nail and a negative mycological culture mycological cure , < 25% of nail impairment and a negative mycological culture clinical improvement , < 25% of nail impairment and a positive mycological culture therapeutic failure , unchanged clinical examination or worsening and a positive mycological culture.
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Using Prescription Lamisil Tablets
Lamisil is available by prescription only. Your podiatrist or medical doctor will prescribe this drug if you have fungal infections of the toenails .
As with any prescription medication take Lamisil exactly as prescribed. If youve got questions about this antifungal drug talk to your doctor or pharmacist.
Lamisil can be taken with or without food, and is usually taken once per day. Both dosage and treatment time are largely determined by the severity of your infection.
Be sure to always finish your prescription. Stopping treatment early may not kill all of the fungal organisms resulting in reinfection. Let your doctor know if your infection persists after treatment or worsens.
What Is The Best Home Remedy For Toenail Fungus
Self-care and body awareness can be key in keeping toenail fungus at bay. Wash feet with warm soapy water and pat completely dry to reduce the spread or growth of fungus on the feet. Allow feet to breathe when possible. Protect your feet and wear breathable shoes and clean socks. Change socks regularly and wash in hot water if you are struggling with toenail fungus. Over-the-counter antifungal powders used for treating athleteâs foot can also be used for treating mild cases of toenail fungus.
Avoid nail polish and pedicures that use polish or nail plate coatings. Even though you may want to conceal the discolored or warped look of an infected toenail, allowing maximum air circulation to the nail and skin of the toes is best.
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Lamisil For Toenail Fungus
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Before usingLamisil for toenail fungus, you need to do enough research about this antifungal medication. Just like the other medicines for fungal infections, Lamisil can come with harmful side effects. You must not use it if you are allergic to Terbinafine drugs or suffer from liver problems and have a weakened immune system. Only use prescription toenail fungus medications if you must. If you can treat your nail fungus with all natural supplements, it will always be the best option.
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Lamisil is used to treat a wide variety of fungal infections, but the most common of these is toenail fungus. Toenail fungus, also known as onychomycosis, is a condition that affects millions of people worldwide. In most cases, the symptoms are mild, causing only cosmetic concerns. However, some people could suffer from changes in the nail structure which may even lead to pain.
There are also cases where toenail fungus can become notoriously difficult to treat, mainly because the fungus will thrive throughout the nail, including in the nail bed. In addition, the structure of the nail has made it hard for some topical medications to penetrate. One of the most common treatments for toenail fungus is Lamisil. But it would be best to see a doctor before usingLamisil for toenail fungus.
What Is Lamisil?
Safety Precautions When Using Lamisil for Toenail Fungus
How Supplied/storage And Handling
LamisilTablets are supplied as white to yellow-tinged white circular, biconvex, beveled tablets containing 250 mg of terbinafine imprinted with Lamisil in circular form on one side and code 250 on the other.
Bottles of 100 tablets NDC 0078-0179-05
Bottles of 30 tablets NDC 0078-0179-15
Store Lamisil Tablets below 25°C in a tight container. Protect from light.
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Before You Take Lamisil Tablets
When you must not take it
Do not take Lamisil if you have ever had an allergic reaction to:
- Terbinafine, the active ingredient, or to any of the other ingredients listed here
- Any other medicines, foods, preservatives or dyes.
Your doctor will want to know if you are prone to allergies.
Some of the symptoms of an allergic reaction may include:
- Shortness of breath
- Swelling of the face, lips, tongue or other parts of the body
- Rash, itching or hives on the skin.
Do not take Lamisil tablets:
- If you have any problems with your kidneys
- If you have or ever had a problem with your liver.
This medicine is not recommended if you currently have a liver problem because it may make the problem worse. If you had a liver problem in the past and your liver is functioning normally now, your doctor may prescribe Lamisil tablets but may want to check your liver function before and during treatment with this medicine. Your doctor might take blood tests to monitor your liver function. In case of abnormal test results, he or she may ask you to stop taking Lamisil.
Do not take Lamisil tablets after the expiry date printed on the pack, or if the packaging is torn or shows signs of tampering. In that case, return it to your pharmacist.
Before you start to take it
Tell your doctor if you:
If you are not sure whether you should start taking Lamisil tablets, talk to your doctor or pharmacist.
Taking other medicines
Some medicines and Lamisil tablets may interfere with each other. These include:
How Should This Medicine Be Used
Terbinafine comes as granules and as a tablet to take by mouth. Terbinafine granules are usually taken with a soft food once a day for 6 weeks. Terbinafine tablets are usually taken with or without food once a day for 6 weeks for fingernail infections and once a day for 12 weeks for toenail infections. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take terbinafine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
To prepare a dose of terbinafine granules, sprinkle the entire packet of granules onto a spoonful of soft food such as pudding or mashed potatoes. Do not sprinkle the granules onto a fruit-based soft food, such as applesauce. If your doctor has told you to take 2 packets of terbinafine granules, you may sprinkle the contents of both packets onto one spoonful, or you may sprinkle each packet onto a separate spoonful of soft food.
Swallow the spoonful of granules and soft food without chewing.
Your fungus may not be completely cured until a few months after you finish taking terbinafine. This is because it takes time for a healthy nail to grow in.
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Dosage Forms & Strengths
4 years : 125 mg/day PO for 6 weeks
4 years : 187.5 mg/day PO for 6 weeks
4 years : 250 mg/day PO for 6 weeks
Serious – Use Alternative
- metoclopramide intranasal
terbinafine will increase the level or effect of metoclopramide intranasal by affecting hepatic enzyme CYP2D6 metabolism. Avoid or Use Alternate Drug. Concurrent use of metoclopramide intranasal and strong CYP2D6 inhibitors is not recommended since the metoclopramide intranasal dose cannot be adjusted.
- pacritinib
terbinafine will decrease the level or effect of pacritinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.
- Saccharomyces boulardii
terbinafine decreases effects of Saccharomyces boulardii by unspecified interaction mechanism. Avoid or Use Alternate Drug. Systemic or oral antifungals may decrease activity of probiotic.
Monitor Closely
Minor
Elevated liver function test results
Visual disturbance
How To Use Terbinafine Spray
Put the spray on the infected area once or twice a day for 1 to 2 weeks.
If you’re using the spray on the area between your toes, or on your bottom or groin, you can cover the skin with a clean strip of gauze afterwards. This type of light dressing is available to buy at pharmacies and is especially helpful to use at night.
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Minor Side Effects From Terbinafine
Some minor and common side effects of terbinafine include:
Diarrhea, nausea, and/or general gastrointestinal distress or abdominal pain
Skin Rash
Headaches of varying severity
Abnormal liver function tests
These side effects, again, can vary in severity, and an abnormal liver function test is not necessarily cause for alarm. Consult your doctor with any questions.
What If I Forget To Take It Or Use It
If you forget to use your terbinafine cream, gel or spray, do not worry. Just apply it as soon as you remember and then keep following your usual routine.
If you forget to take a terbinafine tablet, take it as soon as you remember, unless it’s nearly time for your next dose. In this case, just skip the missed dose and take your next one as normal until you have finished the course.
Do not take a double dose to make up for a missed dose.
If you forget doses often, it may help to set an alarm to remind you. You could also ask your pharmacist for advice on other ways to remember your medicines.
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What Is Terbinafine
Terbinafine, an FDA approved drug also known by the brand name Lamisil, is a medication used to treat fungal infections. Specifically, terbinafine is used to treat fungal infections of the fingernails or toenails . While fighting nail fungus is the main function, terbinafine can also used orally to treat scalp issues and improve hair follicle health in children four years old or older.
Who Can Use Lamisil
If you complete a consultation form we can tell you if Lamisil tablets areappropriate for you. We will not be able to prescribe Lamisil if you are pregnantor breastfeeding, or if you think you may be allergic to terbinafine or any of theother ingredients in the tablets.
Special advice will be needed if you have medical conditions affecting yourliver or kidneys, or if you have psoriasis or systemic lupus erythematosis .Other types of medicines may interfere with Lamisil. We will be able to advise youabout this once we have all your details.
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While You Are Taking Lamisil Tablets
Things you must do
Make sure to take your tablet every day and continue taking it until your doctor tells you to stop. This will ensure that all of the infection is gone and will lessen the chance of the infection coming back once you stop taking this medicine.
Make sure to have any blood tests done that are ordered by your doctor. Any side effects on your liver, kidneys or blood can be detected by blood tests.
Tell your doctor immediately if you notice any of the following:
- Flu-like symptoms
- Any other signs of infection, apart from the fungal infection you are being treated for.
If you become pregnant while taking Lamisil tablets, tell your doctor immediately. Your doctor can discuss with you the risks and benefits of taking it during pregnancy.
Remind your doctor and pharmacist that you are taking Lamisil tablets if you are about to be started on any new medicine.
Tell any other doctor, dentist or pharmacist, who treats you that you are taking Lamisil tablets.
Things you must not do
Do not give this medicine to anyone else, even if their condition seems similar to yours.
Do not use it to treat any other complaints unless your doctor tells you to.
Things to be careful of
Be careful to keep the infected areas dry and cool and change clothing that is in direct contact with the infected areas every day. This will help to clear up the infection and make sure that it does not return.
How Should I Take Lamisil
Take Lamisil exactly as prescribed by your doctor. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
You may take the tablet with or without food.
Lamisil granules should be sprinkled into a spoonful of pudding or mashed potatoes . Swallow this mixture right away without chewing. Do not save the mixture for later use.
Lamisil is usually taken for 6 weeks to treat scalp or fingernail infections, and for 12 weeks to treat a toenail infection.
Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antifungal medicine. Terbinafine will not treat a viral infection such as the flu or a common cold.
While using this medicine, you may need frequent blood tests.
It may take several months for your nails to return to their normal appearance after your treatment with Lamisil.
Store at room temperature away from moisture, heat, and light. Keep the oral granules in their sealed packet until you are ready to use.
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Urgent Advice: Contact 111 For Advice Now If:
- You take a lot of terbinafine tablets at the same time even if you have no side effects.
- You take 2 or more terbinafine tablets and have side effects.
Side effects may include stomach pain, feeling or being sick, diarrhoea, headache or feeling dizzy.
Call or go to 111.nhs.uk
If you need to go to hospital take the packaging, or the leaflet that came with your medicine, and any remaining medicine with you.
What Other Information Should I Know
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before you begin treatment and during your treatment.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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Before Taking This Medicine
You should not use Lamisil if you are allergic to terbinafine, or if you have:
To make sure Lamisil is safe for you, tell your doctor if you have ever had:
-
liver problems
-
weak immune system or
It is not known whether terbinafine will harm an unborn baby. You should wait until after your pregnancy to start treating your nail or scalp infection with Lamisil. Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Terbinafine can pass into breast milk and may harm a nursing baby. You should not breast-feed while using this medicine.
